Urocortin, human( ?Urocortin (human) | Human urocortin | Human urocortin 1 | Human urocortin I )

Catalog No. M23791 CAS No. 176591-49-4

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HNMR

HPLC

MSDS

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Product Name

Urocortin, human
Note

Research use only, not for human use.
Brief Description

Urocortin (Ucn) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF).
Description

Urocortin (Ucn) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF).
In Vitro

Urocortin, human is a selective agonist of CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α and mouse CRF2β receptors in cell assay, respectively.
In Vivo

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior.
Synonyms

?Urocortin (human) | Human urocortin | Human urocortin 1 | Human urocortin I
Pathway

Others
Target

Other Targets
Recptor

CRF2?
Research Area

——
Indication

——

CAS Number

176591-49-4
Formula Weight

4696.32
Molecular Formula

C204H337N63O64
Purity

>98% (HPLC)
Solubility

——
SMILES

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Chemical Name

——

1.Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.

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